Sort by:
Filters:
In the last seven days, 182 new articles where published in 25 top journals in the field of medicine general internal.
Major topics on this page:
JAMA | Review | 2024 Oct 15
Vaughn VM and Others
CONCLUSIONS: Community-acquired pneumonia is common and may result in sepsis, acute respiratory distress syndrome, or death. First-line therapy varies by disease severity and etiology. Hospitalized patients with suspected bacterial CAP and without risk factors for resistant bacteria can be treated with β-lactam/macrolide combination therapy, such as ceftriaxone combined with azithromycin, for a minimum of 3 days.
JAMA | Comment | 2024 Oct 15
Palmqvist S and Others
IMPORTANCE: An accurate blood test for Alzheimer disease (AD) could streamline the diagnostic workup and treatment of AD.
Nature reviews. Disease primers | Review | 2024 Oct 10
Puri P and Others
Primary vesicoureteral reflux (VUR) is one of the most common urological abnormalities in infants and children. The association of VUR, urinary tract infection (UTI) and renal parenchymal damage is well established. The most serious complications of VUR-associated reflux nephropathy are hypertension and proteinuria with chronic kidney disease. Over the past two decades, our understanding of the natural history of VUR has improved, which has helped to identify patients at increased risk of both VUR and VUR-associated renal injury. The main goals in the treatment of paediatric patients with VUR are the prevention of recurrent UTIs and minimizing the risk of renal scarring and long-term renal impairment. Currently, there are four options for managing primary VUR in infants and children: surveillance or intermittent treatment of UTIs with management of bladder and bowel dysfunction; continuous antibiotic prophylaxis; endoscopic subureteral injection of tissue-augmenting substances; and ureteral reimplantation via open, laparoscopic or robotic-assisted surgery. Current debates regarding key aspects of management include when to perform diagnostic imaging and how to best identify the paediatric patients that will benefit from continuous antibiotic prophylaxis or surgical intervention, including endoscopic injection therapy and minimally invasive ureteral reimplantation. Evolving technologies, such as artificial intelligence, have the potential to assist clinicians in the decision-making process and in the individualization of diagnostic imaging and treatment of infants and children with VUR in the future.
JAMA | Comment | 2024 Oct 15
Lu Y and Others
IMPORTANCE: Plasma biomarkers show promise for identifying Alzheimer disease (AD) neuropathology and neurodegeneration, but additional examination among diverse populations and throughout the life course is needed.
JAMA | Journal Article | 2024 Oct 9
Grossman D and Others
Last day on Trephine
No abstract available
JAMA | Journal Article | 2024 Oct 15
Cavazzoni P and Others
No abstract available
BMC medicine | Review | 2024 Oct 11
Liu N and Others
CONCLUSIONS: Although some adverse pregnancy outcomes have clinically promising associations with risk of several cancers in both mother and offspring, it is essential to conduct additional research to solidify the evidence, evaluate causality, and ascertain clinical utility.
Lancet (London, England) | Journal Article | 2024 Oct 12
Saleh E and Others
No abstract available
JAMA | Historical Article | 2024 Oct 15
No authors listed
No abstract available
PLoS medicine | Review | 2024 Oct
Robinson E and Others
In this perspective, we discuss why current mechanistic uncertainty on ultraprocessed foods (UPFs) and health acts as a major challenge to providing informed dietary guidelines and public advice on UPFs. Based on the balance of current evidence, we do not believe it is appropriate to be advising consumers to avoid all UPFs and we await further evidence to inform consumer guidance on the need to limit consumption of specifics foods based on their degree or type of processing.
QJM : monthly journal of the Association of Physicians | Journal Article | 2024 Oct 9
Gupta N and Others
Last day on Trephine
No abstract available
BMC medicine | Journal Article | 2024 Oct 11
Ning C and Others
CONCLUSIONS: These findings highlight the extensive distribution of pleiotropic genetic determinants between HASVs and neuropsychiatric traits. Moreover, they suggest a significant potential for effectively managing and intervening in these diseases during their early stages.
JAMA | Journal Article | 2024 Oct 9
Davis CL and Others
Last day on Trephine
No abstract available
JAMA | Journal Article | 2024 Oct 9
Ard JD and Others
Last day on Trephine
No abstract available
Lancet (London, England) | Journal Article | 2024 Oct 12
Balasegaram M and Others
No abstract available
JAMA | Historical Article | 2024 Oct 15
Robinson JD and Others
No abstract available