The Journal of bone and joint surgery. American volumeReview
19 Feb 2025
Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.
Abstract
➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis. ➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo. ➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.
➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.
COI Statement
Disclosure: Matthew B. Greenblatt is supported by the National Institutes of Health (NIH) under awards R01AR075585, R01HD115274, and R01CA282815, a Career Award for Medical Scientists from the Burroughs Welcome Foundation, a Marfan Foundation Innovator Award, the Mary Kay Ash Foundation, the Mathers Foundation, and a Pershing Square Foundation MIND Prize. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article ( http://links.lww.com/JBJS/I321 ).
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