Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.

Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis. ➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo. ➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.

➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

COI Statement

Disclosure: Matthew B. Greenblatt is supported by the National Institutes of Health (NIH) under awards R01AR075585, R01HD115274, and R01CA282815, a Career Award for Medical Scientists from the Burroughs Welcome Foundation, a Marfan Foundation Innovator Award, the Mary Kay Ash Foundation, the Mathers Foundation, and a Pershing Square Foundation MIND Prize. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article ( http://links.lww.com/JBJS/I321 ).

References:

Owen M Marrow stromal stem cells. J Cell Sci Suppl. 1988;10:63–76.
Owen M, Friedenstein AJ. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988;136:42–60.
Ashton BA, Allen TD, Howlett CR, Eaglesom CC, Hattori A, Owen M. Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop Relat Res. 1980. Sep;(151):294–307.
Bennett JH, Joyner CJ, Triffitt JT, Owen ME. Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci. 1991. May;99(Pt 1):131–9.
Beresford JN. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop Relat Res. 1989. Mar;(240):270–80.

Article info

Journal issue:

Volume: 107
Issue: 4

Doi:

10.2106/JBJS.24.00905

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Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.

Abstract

➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

COI Statement

References:

Owen M Marrow stromal stem cells. J Cell Sci Suppl. 1988;10:63–76.
Owen M, Friedenstein AJ. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988;136:42–60.
Ashton BA, Allen TD, Howlett CR, Eaglesom CC, Hattori A, Owen M. Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop Relat Res. 1980. Sep;(151):294–307.
Bennett JH, Joyner CJ, Triffitt JT, Owen ME. Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci. 1991. May;99(Pt 1):131–9.
Beresford JN. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop Relat Res. 1989. Mar;(240):270–80.