The evolution of tenecteplase as a bridging agent for acute ischemic stroke.

COI Statement

Competing interests: SF, JPO received speakers honoraria from AstraZeneca, Bayer, Boehringer Ingelheim. GC, PP report no disclosures. EIL has shareholder/ownership interests in NeXtGen Biologics, RAPID Medical, Claret Medical, Cognition Medical, Imperative Care (formerly the Stroke Project), Rebound Therapeutics, StimMed, and Three Rivers Medical; serves as national principal investigator or on steering committees for Medtronic (merged with Covidien Neurovascular) SWIFT Prime and SWIFT Direct Trials; receives honoraria from Medtronic (training and lectures); is a consultant for Claret Medical, GLG Consulting, Guidepoint Global, Imperative Care, Medtronic, Rebound, and StimMed; serves on the advisory board for Stryker (AIS Clinical Advisory Board), NeXtGen Biologics, MEDX, Cognition Medical, and Endostream Medical; and is site principal investigator for the CONFIDENCE study (MicroVention), STRATIS Study–Sub I (Medtronic). AHS has financial interest/investor/stock options/ownership in Adona Medical, Inc, Amnis Therapeutics (purchased by Boston Scientific, October 2017), Blink TBI Inc., Buffalo Technology Partners Inc., Cerebrotech Medical Systems, Inc., Cognition Medical, Endostream Medical Ltd., Imperative Care, International Medical Distribution Partners, Neurovascular Diagnostics Inc., Q’Apel Medical Inc, Rebound Therapeutics Corp. (purchased in 2019 by Integra Lifesciences Corp.), Rist Neurovascular Inc., Sense Diagnostics, Inc., Serenity Medical Inc., Silk Road Medical, Spinnaker Medical, Inc., StimMed, Synchron, Three Rivers Medical Inc., Vastrax, LLC, VICIS, Inc., ViseonInc; serves as a consultant/advisory board member for Amnis Therapeutics, Boston Scientific, Canon Medical Systems USA Inc., Cerebrotech Medical Systems Inc., Cerenovus, Corindus Inc., Endostream Medical Ltd., Imperative Care, Inc. Integra LifeSciences Corp., Medtronic, MicroVention, MinnetronixNeuro, Inc., Northwest University–DSMB Chair for HEAT Trial, Penumbra, Q’Apel Medical Inc., Rapid Medical, Rebound Therapeutics Corp. (purchased by Integra LifeSciences Corp.), Serenity Medical Inc., Silk Road Medical, StimMed, Stryker, Three Rivers Medical, Inc., VasSol, and W.L. Gore & Associates; and is principal investigator/steering committee member for the following trials: Cerenovus NAPA and ARISE II; Medtronic SWIFT PRIME and SWIFT DIRECT; MicroVention FRED & CONFIDENCE; MUSC POSITIVE; and Penumbra 3D Separator, COMPASS, INVEST, TIGER. RC received speakers honoraria from Microvention, Medtronic, Balt, Siemens.