Italian journal of pediatricsLetter
12 Oct 2024
Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection.
Abstract
Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV.
However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients.
A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease.
COI Statement
The authors declare that they have no conflict of interest.
References:
- Hu H, Deng H, Bi J, Xu Y, Li S, Xie Y, et al. Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in china: A multicenter retrospective study. Pediatr Investig. 2021;5(3):188–94.
- Ali AF, Liu J, Shang S, Chen Y. Multidisciplinary treatment of chronic active epstein-barr virus infection with multiple complications: a case report. Transl Pediatr. 2021;10(9):2402–6.
- Munz C. Cytotoxicity in epstein barr virus specific immune control. Curr Opin Virol. 2021;46:1–8.
- Long HM, Meckiff BJ, Taylor GS. The t-cell response to epstein-barr virus-new tricks from an old dog. Front Immunol. 2019;10:2193.
- Hou W, Wu X. Diverse functions of gammadelta t cells in the progression of hepatitis b virus and hepatitis c virus infection. Front Immunol. 2020;11:619872.
More resources:
Share: