Cancer cellReview
14 Oct 2024
Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC).
Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including peritoneal, hematogenous, lymphatic, and nerve-related. Understanding the underlying mechanisms is necessary to improve treatment strategies for this challenging disease.
Declaration of interests A.K.S. declares consulting fees from Merck, Kiyatec, Onxeo, ImmunoGen, GSK, Iylon, and AstraZeneca.
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