Hematology:
In the last seven days, 290 new articles where published in 25 top journals in the field of hematology.
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Blood | Review | 2025 Apr 3
Classification and risk stratification in T-lineage acute lymphoblastic leukemia.
Pölönen P and Others
Cure rates for patients with acute lymphoblastic leukemia (ALL) have improved markedly in recent decades, in part because of risk stratification incorporating leukemia genomics, response to treatment, and clinical features to be able to determine at diagnosis which patients are more likely to relapse or have refractory disease. Although risk stratification is well developed for patients with B-lineage ALL, it remains challenging for those with T-lineage ALL (T-ALL). Prognostic factors validated across clinical trials and real-world data in T-ALL include age, central nervous system involvement, and measurable residual disease (MRD) response. Immunophenotype, including early T-cell precursor ALL, is widely used to classify T-ALL but is not consistently associated with outcome in multivariable risk models. Historically, few genetic alterations have been consistently associated with outcome, but recent comprehensive, large-scale genomic profiling has identified multiple genetic subtypes and alterations associated with outcome independent of MRD. This review highlights ongoing efforts to identify reliable prognostic biomarkers and underscores the potential of genomics-based classification to guide future T-ALL treatment strategies.
Haematologica | Journal Article | 2025 Apr 1
Isatuximab, pomalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: the Italian, multicenter, retrospective clinical experience with 270 cases outside of controlled clinical trials.
Martino EA and Others
No abstract available
American journal of hematology | Journal Article | 2025 Apr
Hyperparathyroidism and the Hematologist.
Oun H and Others
No abstract available
Arteriosclerosis, thrombosis, and vascular biology | News | 2025 Apr
ATVB Journal Awards at Vascular Discovery.
Schmidt AM
No abstract available
Haematologica | Journal Article | 2025 Apr 1
Teclistamab in relapsed refractory multiple myeloma: a multi-institutional real-world study from the French early access program.
Perrot A and Others
No abstract available
Blood | Review | 2025 Apr 3
The present and future of CAR T-cell therapy for adult B-cell ALL.
Rampotas A and Others
Chimeric antigen receptor T-cell therapy (CAR-T) targeting CD19 has transformed the management of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), with the US Food and Drug Administration approval of tisagenlecleucel for pediatric/young adult patients and brexucabtagene autoleucel for adults. Efficacy is contingent upon several factors including disease burden. Emerging data suggest that bridging therapy, lymphodepletion, and, for some patients, consolidation therapy have an important role in the success of treatment. Furthermore, strategies to define and manage immunotoxic side effects including hematotoxicity is critical to safe delivery. Advancements in CAR-T design beyond CD19 represent an ongoing therapeutic evolution. Overall, CAR-T signifies a paradigm shift in B-ALL management, with the potential for improved remission and survival in a historically challenging patient population.
American journal of hematology | Letter | 2025 Apr
BTK Inhibitors Versus Venetoclax as First- or Second-Line Therapy in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Real-World Evidence Study.
Roeker LE and Others
No abstract available
American journal of hematology | Letter | 2025 Apr
Prospective Pharmacokinetic Evaluation of Venetoclax in AML Supports Re-Evaluation of Recommended Dose Adjustments With Azole Antifungals.
Kawedia JD and Others
No abstract available
The Lancet. Haematology | Journal Article | 2025 Apr
Peripheral T-cell lymphoma in the Latin American population.
Domingo Domenech E
No abstract available
Haematologica | Journal Article | 2025 Apr 1
Primary myelofibrosis progression: a game of cellular telephone.
Wadley L and Others
No abstract available
The Lancet. Haematology | Journal Article | 2025 Apr
CAR T-cell therapy in LMICs: approval of talicabtagene autoleucel in India.
Paruzzo L and Others
No abstract available
American journal of hematology | Letter | 2025 Apr
A Case of Hodgkin Lymphoma in a Gaucher Disease Patient: Distinguishing Gaucher and Pseudo-Gaucher Cells.
Scaramellini N and Others
No abstract available
Haematologica | Journal Article | 2025 Apr 1
Dexamethasone is associated with reduced frequency and intensity of cytokine release syndrome compared with alternative corticosteroid regimens as premedication for glofitamab in patients with relapsed/refractory large B-cell lymphoma.
Falchi L and Others
No abstract available
Haematologica | Journal Article | 2025 Apr 1
Letermovir prophylaxis for cytomegalovirus is associated with risk of post-transplant lymphoproliferative disorders after haploidentical stem cell transplantation.
Pei XY and Others
No abstract available
Haematologica | Journal Article | 2025 Apr 1
Depletion of the RNA binding protein QKI and circular RNA dysregulation in T-cell acute lymphoblastic leukemia.
Buratin A and Others
No abstract available
The Lancet. Haematology | Journal Article | 2025 Apr
Now where do we STAND with crizanlizumab?
Mendez-Marti S and Others
No abstract available
American journal of hematology | Letter | 2025 Apr
Impact of Pre-Treatment Comorbidity Burden on Survival in Patients Receiving Venetoclax Plus Hypomethylating Agents.
Marconi G and Others
Expectation of survival of patients receiving HMA + VEN is influenced by pre-treatment comorbidity burden.
The Lancet. Haematology | Published Erratum | 2025 Apr
Correction to Lancet Haematol 2025; 12: e128-37.
No authors listed
No abstract available
The Lancet. Haematology | Published Erratum | 2025 Apr
Correction to Lancet Haematol 2025; 12: e120-27.
No authors listed
No abstract available