The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development.

Abstract

In recent years, remarkable technological advances have illuminated aspects of the pathogenesis of myeloid malignancies-yet outcomes for patients with these devastating diseases have not significantly improved.

We posit that a synthesized view of the three dimensions through which hematopoietic cells transit during their healthy and diseased life-clonal evolution, stem cell hierarchy, and ontogeny-promises high yields in new insights into disease pathogenesis and new therapeutic avenues.

COI Statement

No disclosures were reported.

References:

Doulatov S, Notta F, Laurenti E, Dick JE. Hematopoiesis: a human perspective. Cell Stem Cell 2012;10:120–36.
Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, et al. . Tracing the origins of relapse in acute myeloid leukaemia to stem cells. Nature 2017;547:104–8.
Zeng AGX, Bansal S, Jin L, Mitchell A, Chen WC, Abbas HA, et al. . A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia. Nat Med 2022;28:1212–23.
Ivanovs A, Rybtsov S, Ng ES, Stanley EG, Elefanty AG, Medvinsky A. Human haematopoietic stem cell development: from the embryo to the dish. Development 2017;144:2323–37.
Alpar D, Wren D, Ermini L, Mansur MB, van Delft FW, Bateman CM, et al. . Clonal origins of ETV6-RUNX1+ acute lymphoblastic leukemia: studies in monozygotic twins. Leukemia 2015;29:839–46.

Article info

Journal issue:

Volume: 6
Issue: 2

Doi:

10.1158/2643-3230.BCD-24-0235

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