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In the last seven days, 143 new articles where published in 25 top journals in the field of hematology.
Major topics on this page:
Blood advances | Journal Article | 2025 Mar 25
Gore SD
No abstract available
Circulation research | Journal Article | 2025 Mar 28
Wang C and Others
CONCLUSIONS: These data reveal a novel regulation of lysine β-hydroxybutyrylation on PHD2 and demonstrate a promising and therapeutic role for β-OHB/PHD2 in effectively accelerating neovascularization and preserving heart function after cardiac ischemia.
Blood | Journal Article | 2025 Mar 27
Bakhshi TJ and Others
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Chen R and Others
No abstract available
Arteriosclerosis, thrombosis, and vascular biology | News | 2025 Apr
Schmidt AM
New article
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Robles JM and Others
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Luo X and Others
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Dong JF and Others
No abstract available
Thrombosis and haemostasis | Journal Article | 2025 Mar 24
Mauro MS and Others
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Hong X and Others
No abstract available
Blood | Journal Article | 2025 Mar 27
Calo-Pérez A and Others
No abstract available
Blood cancer journal | Letter | 2025 Mar 27
Pérez-Escurza O and Others
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Ter Avest M and Others
No abstract available
HemaSphere | Journal Article | 2025 Mar
Lesan V and Others
No abstract available
Blood advances | Journal Article | 2025 Mar 25
Cannova J and Others
No abstract available
Leukemia | Journal Article | 2025 Mar 24
Bröckelmann PJ and Others
No abstract available
Blood | Journal Article | 2025 Mar 27
Adès L
No abstract available
Blood cancer journal | Letter | 2025 Mar 28
Pullarkat V and Others
No abstract available
Blood | Editorial | 2025 Mar 27
Achyutuni S and Others
No abstract available
Journal of hematology & oncology | Review | 2025 Mar 28
Jia H and Others
Cancer-associated fibroblasts (CAFs) are key players in cancer development and therapy, and they exhibit multifaceted roles in the tumor microenvironment (TME). From their diverse cellular origins, CAFs undergo phenotypic and functional transformation upon interacting with tumor cells and their presence can adversely influence treatment outcomes and the severity of the cancer. Emerging evidence from single-cell RNA sequencing (scRNA-seq) studies have highlighted the heterogeneity and plasticity of CAFs, with subtypes identifiable through distinct gene expression profiles and functional properties. CAFs influence cancer development through multiple mechanisms, including regulation of extracellular matrix (ECM) remodeling, direct promotion of tumor growth through provision of metabolic support, promoting epithelial-mesenchymal transition (EMT) to enhance cancer invasiveness and growth, as well as stimulating cancer stem cell properties within the tumor. Moreover, CAFs can induce an immunosuppressive TME and contribute to therapeutic resistance. In this review, we summarize the fundamental knowledge and recent advances regarding CAFs, focusing on their sophisticated roles in cancer development and potential as therapeutic targets. We discuss various strategies to target CAFs, including ECM modulation, direct elimination, interruption of CAF-TME crosstalk, and CAF normalization, as approaches to developing more effective treatments. An improved understanding of the complex interplay between CAFs and TME is crucial for developing new and effective targeted therapies for cancer.